Co-disposition of chitosan nanoparticles by multi types of hepatic cells and their subsequent biological elimination: the mechanism and kinetic studies at the cellular and animal levels
Abstract
Background: The clearance of nanomaterials (NMs) from the liver is essential for clinical safety, and their hepatic clearance is primarily determined by the co-disposition process of various types of hepatic cells. Studies of this process and the subsequent clearance routes are urgently neede …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
cell line
nanoparticles / chemistry*
liver / metabolism
kinetics
macrophages / metabolism
biological transport
yu-ting bai
pmid:31534335
pmc6681437
doi:10.2147/ijn.s208496
li-qun jiang
ting-yu wang
chitosan / pharmacology*
drug carriers / metabolism
exocytosis
hepatocytes / cytology*
hepatocytes / drug effects
hepatocytes / metabolism*
nanoparticles / ultrastructure
photons
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274527
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