Long noncoding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6/Mll1-mediated H3K4me3
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Long noncoding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6/Mll1-mediated H3K4me3

Yan Jin;Bowen Zhang;Junxia Lu;Yingdong Song;Wei Wang;Wei Zhang;Fanghong Shao;Meng Gong;Meiting Wang;Xiaolin Liang;Shuqin Li;Zhi Zhang;Ge Shan;Xiangting Wang;
plos biology 2021 Vol. 19 pp. e3001297-
187
jin2021ploslong

Abstract

The long non-coding RNA lncRNA-PM activates transcription of the cerebellar synaptic organizer Cbln1 by promoting Pax6-Mll1-mediated H3K4me3 methylation, thereby helping to maintain cerebellar synaptic integrity and motor function.

Keywords

gene expression methylation cerebellum gene regulation long non-coding rna rna sequencing small interfering rna synapses

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DOI:
10.1371/journal.pbio.3001297
URL:
https://journals.plos.org/plosbiology/article?id=1...

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ID: 274493
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