The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
Abstract
Some pathogens (e.g., Mycobacterium tuberculosis, Toxoplasma gondii, Leishmania spp) have been shown to persist in their host after clinical cure, establishing the risk of disease reactivation. We analyzed the conditions necessary for the long term maintenance of Leishmania major in genetically resi …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
Antibodies
Monoclonal / therapeutic use*
Receptors
Knockout
cd8-positive t-lymphocytes / immunology
cd4-positive t-lymphocytes / immunology
skin / immunology
leishmaniasis
interferon-gamma / physiology
interleukin-4 / physiology
interleukin-10 / physiology*
pmid:11714756
pmc2193677
doi:10.1084/jem.194.10.1497
y belkaid
k f hoffmann
d l sacks
leishmania major / physiology*
cutaneous / therapy*
interleukin / antagonists & inhibitors*
interleukin-10
skin / parasitology*
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Citation
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274376
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