Effect of Prenatal Drug Administration on Maternal and Neonatal Platelet Aggregation and PF4 Release
J.M. Whaun;G.R. Smith;V.A. Sochor;
Pathophysiology of Haemostasis and Thrombosis1980Vol. 9pp. 226-237
135
whaun1980pathophysiologyeffect
Abstract
Release of platelet antiheparin activity (platelet factor 4, PF4) induced by collagen and l-epinephrine, is normal in newborn infants without antenatal drug exposure. In contrast, PF4 release in platelets of infants of mothers with membrane-stabilizing drug ingestion is decreased to a greater extent than in their respective mothers. Platelet aggreg