Effect of Prenatal Drug Administration on Maternal and Neonatal Platelet Aggregation and PF4 Release

Effect of Prenatal Drug Administration on Maternal and Neonatal Platelet Aggregation and PF4 Release

J.M. Whaun;G.R. Smith;V.A. Sochor;
Pathophysiology of Haemostasis and Thrombosis 1980 Vol. 9 pp. 226-237
135
whaun1980pathophysiologyeffect

Abstract

Release of platelet antiheparin activity (platelet factor 4, PF4) induced by collagen and l-epinephrine, is normal in newborn infants without antenatal drug exposure. In contrast, PF4 release in platelets of infants of mothers with membrane-stabilizing drug ingestion is decreased to a greater extent than in their respective mothers. Platelet aggreg

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