Effects of in vitro hypoxia and lowered pH on potassium fluxes and energy metabolism in rat brain synaptosomes
Abstract
Synaptosomes isolated on isosmotic Ficoll density gradients are an effective model for some aspects of neuronal function. They maintain metabolic energy levels ([ATP]/[ADP] [Pi]) and transplasma membrane electrical potentials very similar to those of neurons in the intact brain. The concentration of …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
male
P.H.S.
Rats
Anaerobiosis
sodium / metabolism
hydrogen-ion concentration
energy metabolism*
calcium / metabolism
brain / metabolism*
adenosine triphosphate / metabolism
brain / ultrastructure
potassium / metabolism*
ouabain / pharmacology
oxygen / metabolism*
synaptosomes / metabolism*
adenosine diphosphate / metabolism
pmid:7463041
doi:10.1111/j.1471-4159.1981.tb02385.x
a pastuszko
d f wilson
i a silver
pentobarbital
synaptosomes / drug effects
veratridine / pharmacology
Citation
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274223
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