National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male aged middle aged Comparative Study 80 and over Clinical Trial Phase III Randomized Controlled Trial Multicenter Study Survival Analysis combined modality therapy positron-emission tomography initials='g' affs=[] is_editor=false suffix=none equal_contrib=false) initials='j' initials='a' initials='h' initials='b' initials='n' initials='w' initials='p' initials='l' initials='bj' initials='k' initials='d' affs=[]) author(firstnames='karim' initials='s' initials='m' initials='o' initials='jm' author(firstnames='jules' author(firstnames='bruno' author(firstnames='frédéric' initials='f' initials='c' author(firstnames='david' author(firstnames='benoit' initials='i' initials='r' author(firstnames='daniel' author(firstnames='anna' initials='e' initials='v' initials='t' suffix='jr' author(firstnames='peter' author(firstnames='robert' initials='x' author(firstnames='andrew' author(firstnames='michael' author(firstnames='james' lastname='gordon' author(firstnames='ronald' initials='u' lastname='hussain' lastname='krause' lastname='morris' author(firstnames='enrique' author(firstnames='simon' author(firstnames='jón' equal_contrib=false)] author(firstnames='anne' author(firstnames='brian' heterocyclic compounds lastname='liu' author(firstnames='johann' author(firstnames='charles' author(firstnames='nicholas' initials='mm' author(firstnames='marcel' author(firstnames='deborah' author(firstnames='matthias' author(firstnames='mathieu' author(firstnames='glenn' author(firstnames='fred' pmid:34161051 pmc8446332 doi:10.1056/nejmoa2107322 oliver sartor johann de bono collabauthor(name='vision investigators' investigators=[author(firstnames='carlos artigas' lastname='guix' initials='ca' lastname='beuselinck' author(firstnames='renaud' lastname='lhommel' author(firstnames='jean-mathieu' lastname='beauregard' author(firstnames='kim' lastname='chi' author(firstnames='urban' lastname='emmenegger' author(firstnames='cristiano' lastname='ferrario' lastname='laidley' lastname='ong' lastname='saad' lastname='buus' author(firstnames='mette moe' lastname='kempel' lastname='petersen' lastname='cazeau' lastname='courbon' lastname='fizazi' author(firstnames='aude' lastname='flechon' lastname='gauthe' author(firstnames='hakim' lastname='mahammedi' lastname='eiber' author(firstnames='ken' lastname='herrmann' author(firstnames='bernd joachim' author(firstnames='kambiz' lastname='rahbar' author(firstnames='bart de' lastname='keizer' lastname='janssen' lastname='lavalaye' lastname='nagarajah' author(firstnames='wouter' lastname='vogel' author(firstnames='irma' lastname='molina-vicenty' lastname='castellanos' author(firstnames='silvia' lastname='johansson' lastname='kindblom' lastname='sundlov' author(firstnames='anders' lastname='widmark' author(firstnames='amit' lastname='bahl' lastname='crabb' lastname='de bono' lastname='enting' lastname='jones' author(firstnames='heather' lastname='payne' author(firstnames='carla' lastname='perna' author(firstnames='nabil' lastname='adra' lastname='armstrong' author(firstnames='hani' lastname='babiker' lastname='bane' author(firstnames='tomasz' lastname='beer' author(firstnames='gholam' lastname='reza berenji' lastname='bubley' lastname='chang' author(firstnames='bennett' lastname='chin' author(firstnames='johannes' lastname='czernin' author(firstnames='ebrahim' lastname='delpassand' lastname='den' lastname='dreicer' author(firstnames='ghassan' lastname='el-haddad' lastname='elliott' lastname='fang' author(firstnames='irfan' lastname='farukhi' author(firstnames='gregg' lastname='franklin' author(firstnames='rohan' lastname='garje' author(firstnames='arif' author(firstnames='ayse' lastname='kendi' author(firstnames='vadim' lastname='koshkin' author(firstnames='frank' author(firstnames='jeff' lastname='michalski' author(firstnames='alicia' lastname='morgans' author(firstnames='luke' lastname='nordquist' author(firstnames='medhat' lastname='osman' author(firstnames='chandler' lastname='park' lastname='petrylak' author(firstnames='morand' lastname='piert' author(firstnames='daniella' lastname='pinho' author(firstnames='oliver' lastname='sartor' author(firstnames='satish' lastname='shah' author(firstnames='neal' lastname='shore' author(firstnames='sandhya' lastname='srinivas' author(firstnames='scott' lastname='tagawa' lastname='tutrone' author(firstnames='nitin' lastname='vaishampayan' lastname='vogelzang' author(firstnames='xiao' lastname='wei' author(firstnames='song' lastname='zhao' dipeptides / therapeutic use* 1-ring / therapeutic use* kallikreins / antagonists & inhibitors* lutetium / adverse effects lutetium / therapeutic use* prostate / diagnostic imaging prostate-specific antigen / antagonists & inhibitors* prostate-specific antigen / therapeutic use* prostatic neoplasms castration-resistant / diagnostic imaging castration-resistant / drug therapy castration-resistant / mortality castration-resistant / radiotherapy* radioisotopes / adverse effects radioisotopes / therapeutic use*