Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator
Abstract
The second messenger cAMP stimulates the expression of a number of target genes via the protein kinase A-mediated phosphorylation of CREB at Ser-133 (Gonzalez, G. A., and Montminy, M. R. (1989) Cell 59, 675-680). Ser-133 phosphorylation enhances CREB activity by promoting interaction with a 265-kDa …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
Nuclear Proteins / metabolism*
Transcription Factors / metabolism*
Promoter Regions
hela cells
recombinant fusion proteins / metabolism
creb-binding protein
trans-activators*
cyclic amp / metabolism
rna polymerase ii / metabolism*
j arias
pmid:8576192
doi:10.1074/jbc.271.5.2373
b l kee
m r montminy
glutathione transferase / metabolism
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274147
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