Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice
Abstract
Combination chemotherapy provided a survival advantage over single-agent treatment of mice inoculated with neurotropic H5N1 influenza virus. This strategy might be an option for the control of pandemic influenza viruses that are sensitive to amantadine. Combinations that include other drugs should b …
Keywords
Administration
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
N.I.H.
Extramural
Inbred BALB C
Viral
drug resistance
microbial sensitivity tests
drug therapy
combination
dose-response relationship
drug
antiviral agents / administration & dosage
antiviral agents / therapeutic use*
oral
drug evaluation
antiviral agents / pharmacology
influenza a virus
preclinical
orthomyxoviridae infections / drug therapy*
orthomyxoviridae infections / virology
amantadine / administration & dosage
oseltamivir / therapeutic use*
amantadine / pharmacology
amantadine / therapeutic use*
oseltamivir / administration & dosage
pmid:17591026
natalia a ilyushina
erich hoffmann
elena a govorkova
h5n1 subtype* / drug effects
h5n1 subtype* / genetics
oseltamivir / pharmacology
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274133
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na2007antiviralamantadine-oseltamivir
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