Systematic Tuning of Heme Redox Potentials and Its Effects on O2 Reduction Rates in a Designed Oxidase in Myoglobin

Systematic Tuning of Heme Redox Potentials and Its Effects on O2 Reduction Rates in a Designed Oxidase in Myoglobin

Ambika Bhagi-Damodaran, Igor D. Petrik, Nicholas M. Marshall, Howard Robinson, Yi Lu;Ambika Bhagi-Damodaran;Igor D. Petrik;Nicholas M. Marshall;Howard Robinson;Yi Lu;
Journal of the American Chemical Society 2014 Vol. 136 pp. 11882-
171
lu2014journalsystematic tuning

Abstract

Cytochrome c Oxidase (CcO) is known to catalyze the reduction of O[2] to H[2] O efficiently with a much lower overpotential than most other O[2] reduction catalysts. However, methods by which the enzyme fine-tunes the reduction potential (E°) ...

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