Systematic
Tuning of Heme Redox Potentials and Its
Effects on O2 Reduction Rates in a Designed Oxidase in
Myoglobin
Ambika Bhagi-Damodaran, Igor D. Petrik, Nicholas M. Marshall, Howard Robinson, Yi Lu;Ambika Bhagi-Damodaran;Igor D. Petrik;Nicholas M. Marshall;Howard Robinson;Yi Lu;
Journal of the American Chemical Society2014Vol. 136pp. 11882-
171
lu2014journalsystematic
tuning
Abstract
Cytochrome c Oxidase (CcO) is
known to catalyze the reduction of O[2] to H[2] O
efficiently with a much lower overpotential than most other O[2] reduction catalysts. However, methods by which the enzyme
fine-tunes the reduction potential (E°) ...