A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion
Abstract
Adult mammalian brains have largely lost neuroregeneration capability except for a few niches. Previous studies have converted glial cells into neurons, but the total number of neurons generated is limited and the therapeutic potential is unclear. Here, we demonstrate that NeuroD1-mediated in situ a …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
treatment outcome
research support
non-u.s. gov't
male
N.I.H.
Extramural
Disease Models
Animal
Rats
Sprague-Dawley
neuroglia / metabolism
transgenic
genetic therapy / methods*
brain ischemia / therapy*
neurons / metabolism*
action potentials
basic helix-loop-helix transcription factors / metabolism
pmid:31551137
pmc6952185
doi:10.1016/j.ymthe.2019.09.003
yu-chen chen
ning-xin ma
gong chen
astrocytes / metabolism*
basic helix-loop-helix transcription factors / genetics*
cellular reprogramming / genetics*
dependovirus / genetics
nerve degeneration / therapy
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274115
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