Informality is a distinguishing trait of economic life across much of the global South. In terms of the tourism sector several researchers examine the informal sector of leisure tourism. In this article the aim is to focus upon business tourism and more specifically the segment of informal sector business tourism. The growth of informal sector business tourism is particularly important in sub-Saharan Africa. An analysis is undertaken of recent research on South Africa’s major city of Johanesburg where the importance of informal sector business tourism is demonstrated. The results show Johannesburg is the focus for transnational entrepreneurship in the form of the growth of cross-border shopping. The organisation of this manifestation of informal business tourism, the nature of its participants and business challenges form the focus of discussion. It is argued that despite many benefits that flow to the city of Johannesburg from informal sector of business tourism the local state has yet to fully acknowledge the multiple positive impacts of these international visitors upon the urban economy and plan to accommodate the needs of cross-border shoppers.