Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Willem M.H. Hoogaars, Angela Engel, Janynke F. Brons, Arie O. Verkerk, Frederik J. de Lange, L.Y. Elaine Wong, Martijn L. Bakker, Danielle E. Clout, Vincent Wakker, Phil Barnett, Jan Hindrik Ravesloot, Antoon F.M. Moorman, E. Etienne Verheijck, Vincent M. Christoffels;Willem M.H. Hoogaars;Angela Engel;Janynke F. Brons;Arie O. Verkerk;Frederik J. de Lange;L.Y. Elaine Wong;Martijn L. Bakker;Danielle E. Clout;Vincent Wakker;Phil Barnett;Jan Hindrik Ravesloot;Antoon F.M. Moorman;E. Etienne Verheijck;Vincent M. Christoffels;
genes & development 2007 Vol. 21 pp. 1098-
111
christoffels2007genestbx3

Abstract

The sinoatrial node initiates the heartbeat and controls the rate and rhythm of contraction, thus serving as the pacemaker of the heart. Despite the crucial role of the sinoatrial node in heart function, the mechanisms that underlie its specification ...

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