Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry
Abstract
The bacteria causing diphtheria, whooping cough, cholera and other diseases secrete mono-ADP-ribosylating toxins that modify intracellular proteins. Here, we describe four structures of a catalytically active complex between a fragment of Pseudomonas aeruginosa exotoxin A (ETA) and its protein subst …
Keywords
catalysis
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Molecular
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
protein conformation
binding sites
bacterial toxins / metabolism*
exotoxins / metabolism*
bacterial toxins / genetics
exotoxins / genetics
x-ray
virulence factors / genetics
crystallography
nad / metabolism
virulence factors / metabolism*
rené jørgensen
a rod merrill
adp ribose transferases / genetics
adp ribose transferases / metabolism*
peptide elongation factor 2 / genetics
peptide elongation factor 2 / metabolism*
pseudomonas aeruginosa / chemistry
pmid:16107839
doi:10.1038/nature03871
gregers r andersen
adp ribose transferases / chemistry*
adenosine diphosphate / metabolism*
bacterial toxins / chemistry*
exotoxins / chemistry*
molecular mimicry*
peptide elongation factor 2 / chemistry*
ribose / metabolism*
ribosomes / chemistry
ribosomes / metabolism*
saccharomyces cerevisiae
virulence factors / chemistry*
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273975
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