Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis
Abstract
During meiosis, homologues become juxtaposed and synapsed along their entire length. Mutations in the cohesin complex disrupt not only sister chromatid cohesion but also homologue pairing and synaptonemal complex formation. In this study, we report that Pds5, a cohesin-associated protein known to re …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
recombination
recombinant fusion proteins / genetics
chromosomes
cell cycle proteins / genetics
cell cycle proteins / metabolism*
recombinant fusion proteins / metabolism
chromosomal proteins
dna topoisomerases
vincent guacci
non-histone / metabolism
fungal / metabolism
dna repair
meiosis / physiology*
saccharomyces cerevisiae* / genetics
type ii / genetics
type ii / metabolism
saccharomyces cerevisiae proteins / genetics
saccharomyces cerevisiae proteins / metabolism*
non-histone / genetics
fungal / ultrastructure
chromosome segregation
pmid:19736318
pmc2742186
doi:10.1083/jcb.200810107
hui jin
hong-guo yu
chromatids / metabolism*
chromosome pairing*
dna breaks
double-stranded
endodeoxyribonucleases
rad51 recombinase / genetics
rad51 recombinase / metabolism
saccharomyces cerevisiae* / metabolism
ubiquitin-protein ligases / genetics
ubiquitin-protein ligases / metabolism
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273965
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