Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins
Abstract
Chromatin immunoprecipitation (ChIP) is the gold-standard technique for localizing nuclear proteins in the genome. We used ChIP, in combination with deep sequencing (Seq), to study the genome-wide distribution of the Silent information regulator (Sir) complex in Saccharomyces cerevisiae. We analyzed …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
N.I.H.
Extramural
polymerase chain reaction
high-throughput nucleotide sequencing
artifacts*
dna primers / genetics
saccharomyces cerevisiae / genetics*
pmid:24173036
pmc3831989
doi:10.1073/pnas.1316064110
leonid teytelman
deborah m thurtle
alexander van oudenaarden
chromatin immunoprecipitation / methods*
genetic loci / genetics*
silent information regulator proteins
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273875
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