Endotoxin fails to induce IFN-gamma in endotoxin-tolerant mice: deficiencies in both IL-12 heterodimer production and IL-12 responsiveness
Balkhy HH;Heinzel FP;;
Journal of immunology (Baltimore, Md. : 1950)1999Vol. 162pp. -
238
hh1999journalendotoxin
Abstract
Mice exposed to sublethal endotoxemia develop short-term endotoxin tolerance, a state characterized by decreased monokine production and enhanced protection against endotoxic lethality. We confirmed that TNF-alpha production is markedly impaired in endotoxin-tolerant mice and additionally found 2- t …