miR-101a and miR-30b contribute to inflammatory cytokine-mediated β-cell dysfunction
Abstract
Inflammatory cytokines have a critical role in the progressive deterioration of pancreatic β-cell function and development of type 1 diabetes. Prolonged exposure of β-cells to inflammatory cytokines results in gene expression modifications, leading to loss of β-cell function. MicroRNAs (miRNAs) are …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
cytokines
micrornas / metabolism*
transcription factors / metabolism
apoptosis
diabetes mellitus
hek293 cells
insulin / biosynthesis
insulin-secreting cells / metabolism*
ying zheng
zhen wang
zhiguang zhou
homeodomain proteins / metabolism
basic helix-loop-helix transcription factors / metabolism
pmid:26367486
doi:10.1038/labinvest.2015.112
type 1 / etiology*
proto-oncogene proteins c-bcl-2 / metabolism
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