BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells
Abstract
Prostate cancer is one of the most common cancers in men. Several lines of evidence have suggested that bone morphogenetic protein (BMP) signals play important roles in the generation and progression of prostate cancers. In the present study, we show that BMP-7 inhibits the proliferation of androgen …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
signal transduction*
cell line
Inbred BALB C
Receptors
cell proliferation*
reverse transcriptase polymerase chain reaction
phosphorylation
up-regulation
tetracycline / pharmacology
androgens / physiology*
transforming growth factor beta / metabolism
bone morphogenetic protein receptors
type i
bone morphogenetic proteins / physiology*
protein-serine-threonine kinases / genetics
growth factor / genetics
cell cycle proteins / metabolism
prostatic neoplasms / pathology*
cyclin-dependent kinase 2
cyclin-dependent kinase inhibitor p21
bone morphogenetic protein 7
pmid:15531927
doi:10.1038/sj.onc.1208127
hideyo miyazaki
tetsuro watabe
kohei miyazono
bone morphogenetic proteins / metabolism
cdc2-cdc28 kinases / antagonists & inhibitors
immunoprecipitation
retinoblastoma protein / metabolism
transforming growth factor beta / physiology*
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273840
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