INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

Schmitt CA;McCurrach ME;de Stanchina E;Wallace-Brodeur RR;Lowe SW;;
genes & development 1999 Vol. 13 pp. -
215
ca1999genesink4a/arf

Abstract

The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor development and treatment response, the Emu-myc transgenic lymphoma model was used to generate genetically defined tumors with mutations in the I …

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