High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes
Abstract
Using high-throughput sequencing, we devised a technique to determine the insertion sites of virtually all members of the human-specific L1 retrotransposon family in any human genome. Using diagnostic nucleotides, we were able to locate the approximately 800 L1Hs copies corresponding specifically to …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
N.I.H.
Extramural
DNA
Sequence Analysis
genome
human / genetics*
retroelements
genetic variation / genetics*
pmid:20488934
pmc2928504
doi:10.1101/gr.106419.110
adam d ewing
haig h kazazian
long interspersed nucleotide elements / genetics*
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273654
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