In this paper, we compare the predictive performance of the adaptive neuro-fuzzy inference system (ANFIS) models according to the input space segmentation method. The ANFIS model can be divided into four types according to the method of dividing the input space. In general, the ANFIS1 model using grid partitioning method, ANFIS2 model using subtractive clustering (SC) method, and the ANFIS3 model using fuzzy C-means (FCM) clustering method exist. In this paper, we propose the ANFIS4 model using a context-based fuzzy C-means (CFCM) clustering method. Context-based fuzzy C-means clustering is a clustering method that considers the characteristics of the output space as well as the input space. Here, the symmetric Gaussian membership functions are obtained by the clusters produced from each context in the design of the ANFIS4. In order to evaluate the performance of the ANFIS models according to the input space segmentation method, a prediction experiment was conducted using the combined cycle power plant (CCPP) data and the auto-MPG (miles per gallon) data. As a result of the prediction experiment, we confirmed that the ANFIS4 model using the proposed input space segmentation method shows better prediction performance than the ANFIS model (ANFIS1, ANFIS2, ANFIS3) using the existing input space segmentation method.