Genetic regressive trajectories in colorectal cancer: A new hallmark of oligo-metastatic disease?
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Genetic regressive trajectories in colorectal cancer: A new hallmark of oligo-metastatic disease?

Ottaiano A;Santorsola M;Caraglia M;Circelli L;Gigantino V;Botti G;Nasti G;;
translational oncology 2021 Vol. 14 pp. -
38
a2021translationalgenetic

Abstract

Colorectal cancer (CRC) originates as consequence of multiple genetic alterations. Some of the involved genes have been extensively studied (APC, TP53, KRAS, SMAD4, PIK3CA, MMR genes) in highly heterogeneous and poly-metastatic cohorts. However, about 10% of metastatic CRC patients presents with an …

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National Center for Biotechnology Information NCBI NLM MEDLINE review pubmed abstract nih national institutes of health national library of medicine pmid:34034007 pmc8144733 doi:10.1016/j.tranon.2021.101131 alessandro ottaiano mariachiara santorsola guglielmo nasti

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