National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. N.I.H. Extramural Cells Cultured Rats dose-response relationship drug kinetics enzyme activation / drug effects cell survival / drug effects molecular conformation structure-activity relationship stereoisomerism pmid:18707138 pmc2559976 doi:10.1021/tx800165c natalia vilariño k c nicolaou luis m botana caspase inhibitors caspases / metabolism cytoskeleton / chemistry cytoskeleton / drug effects furans / chemical synthesis furans / chemistry* furans / toxicity marine toxins / chemical synthesis marine toxins / chemistry* marine toxins / toxicity* pyrans / chemical synthesis pyrans / chemistry* pyrans / toxicity spiro compounds / chemical synthesis spiro compounds / chemistry* spiro compounds / toxicity*