A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
Abstract
Nuclear receptors regulate gene expression by direct activation of target genes and inhibition of AP-1. Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Molecular
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
conserved sequence
P.H.S.
Rats
DNA
Receptors
Base Sequence
Molecular Sequence Data
ligands
cytoplasmic and nuclear / genetics*
cytoplasmic and nuclear / metabolism
transcription factors / metabolism
complementary / genetics
sequence homology
amino acid
nuclear proteins / metabolism
cloning
binding sites / genetics
molecular weight
transcription factors / genetics
gene expression regulation / genetics
fibroblasts / physiology
nuclear proteins / genetics
creb-binding protein
histone acetyltransferases
nuclear receptor coactivator 1
trans-activators*
m g rosenfeld
binding
transcription factors / pharmacology*
pmid:8616895
doi:10.1016/s0092-8674(00)81118-6
y kamei
l xu
competitive / genetics
nuclear proteins / pharmacology*
transcription factor ap-1 / antagonists & inhibitors*
transcriptional activation / drug effects*
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273316
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