Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential
Abstract
Expression of the tyrosine-kinase receptor encoded by the c-KIT proto-oncogene progressively decreases during local tumor growth and invasion of human melanomas. To provide direct evidence that c-KIT plays a role in metastasis of human melanoma, we transfected the c-KIT gene into the c-KIT negative …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
RNA
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
male
P.H.S.
Cultured
phenotype
Inbred BALB C
messenger / metabolism
nude
skin neoplasms / genetics
transfection
tumor cells
apoptosis*
melanoma / genetics
neoplasm proteins / genetics
neoplasm proteins / metabolism*
neoplasm transplantation
skin neoplasms / pathology
m luca
pmid:8957075
s huang
m bar-eli
lung neoplasms / secondary*
melanoma / metabolism*
melanoma / pathology
melanoma / secondary*
proto-oncogene proteins c-kit / genetics
proto-oncogene proteins c-kit / metabolism*
skin neoplasms / metabolism*
stem cell factor / metabolism
stem cell factor / pharmacology*
Access
Citation
ID:
273283
References
Blockchain Verification
Account:
NFT Contract Address:
0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
273283
Unique Identifier:
Network:
Scimatic Chain (ID: 481)
Loading...
Blockchain Readiness Checklist
Authors
Abstract
Journal Name
Year
Title
Creates 1,000,000 NFT tokens for this article
Token Features:
- ERC-1155 Standard NFT
- 1 Million Supply per Article
- Transferable via MetaMask
- Permanent Blockchain Record
Scan with Saymatik Web3.0 Wallet