Central mechanisms involved in the orexigenic actions of ghrelin
Abstract
Ghrelin is a stomach hormone, secreted into the bloodstream, that initiates food intake by activating NPY/AgRP neurons in the hypothalamic acruate nucleus. This review focuses on recent evidence that details the mechanisms through which ghrelin activate receptors on NPY neurons and downstream signal …
Keywords
diet
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
review
gene expression
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
signal transduction*
Receptors
Knockout
neurons / drug effects
neurons / metabolism
eating
energy metabolism
calcium / metabolism
hypothalamus / metabolism*
hypothalamus / drug effects
neuropeptide y / metabolism*
membrane proteins
pmid:21619904
doi:10.1016/j.peptides.2011.05.014
zane b andrews
acyltransferases / genetics
acyltransferases / metabolism
agouti-related protein / genetics
agouti-related protein / metabolism*
appetite regulation / physiology*
high-fat / adverse effects
fasting / adverse effects
gastric mucosa / metabolism
ghrelin / genetics
ghrelin / metabolism*
neuropeptide y / genetics
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Citation
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273273
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