IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge
Abstract
We examined the expression and influence of IL-10 during influenza infection. We found that IL-10 does not impact sublethal infection, heterosubtypic immunity, or the maintenance of long-lived influenza Ag depots. However, IL-10-deficient mice display dramatically increased survival compared with wi …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
N.I.H.
Extramural
Antigens
orthomyxoviridae infections / immunology*
survival rate
viral / immunology
t-lymphocytes
helper-inducer / immunology*
influenza a virus
interleukin-10 / metabolism
h1n1 subtype / immunology*
interleukin-17 / immunology*
interleukin-10 / genetics
interleukin-10 / immunology*
pmid:19494257
pmc2724021
doi:10.4049/jimmunol.0900657
k kai mckinstry
tara m strutt
susan l swain
forkhead transcription factors / immunology
interleukin-10 / deficiency*
orthomyxoviridae infections / genetics
orthomyxoviridae infections / metabolism
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273216
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