Mechanism of action of T-705 against influenza virus
Abstract
T-705, a substituted pyrazine compound, has been found to exhibit potent anti-influenza virus activity in vitro and in vivo. In a time-of-addition study, it was indicated that T-705 targeted an early to middle stage of the viral replication cycle but had no effect on the adsorption or release stage. …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
chromatography
antiviral agents / pharmacology*
rna / biosynthesis
high pressure liquid
orthomyxoviridae / drug effects*
yousuke furuta
amides / pharmacology*
pyrazines / pharmacology*
pmid:15728892
pmc549233
doi:10.1128/aac.49.3.981-986.2005
kazumi takahashi
kimiyasu shiraki
dna / biosynthesis
dna-directed rna polymerases / antagonists & inhibitors
imp dehydrogenase / antagonists & inhibitors
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273113
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