Development and Validation of Clinical Scoring Tool to Predict Outcomes of Treatment With Vedolizumab in Patients With Ulcerative Colitis

Development and Validation of Clinical Scoring Tool to Predict Outcomes of Treatment With Vedolizumab in Patients With Ulcerative Colitis

Dulai PS;Singh S;Casteele NV;Meserve J;Winters A;Chablaney S;Aniwan S;Shashi P;Kochhar G;Weiss A;Koliani-Pace JL;Gao Y;Boland BS;Chang JT;Faleck D;Hirten R;Ungaro R;Lukin D;Sultan K;Hudesman D;Chang S;Bohm M;Varma S;Fischer M;Shmidt E;Swaminath A;Gupta N;Rosario M;Jairath V;Guizzetti L;Feagan BG;Siegel CA;Shen B;Kane S;Loftus EV;Sandborn WJ;Sands BE;Colombel JF;Lasch K;Cao C;;
clinical gastroenterology and hepatology : the official clinical practice journal of the american gastroenterological association 2020 Vol. 18 pp. -
169
ps2020clinicaldevelopment

Abstract

We used data from a trial of patients with UC to develop a scoring system, called the CDST, which identified patients most likely to enter corticosteroid-free remission during vedolizumab therapy, but not anti-TNF therapy. We validated the vedolizumab CDST in a separate cohort of patients in clinica …

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