Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene
Abstract
Regulation of the low density lipoprotein (LDL) receptor promoter by cholesterol requires a well defined sterol regulatory site and an adjacent binding site for the universal transcription factor Sp1. These elements are located in repeats 2 and 3 of the wild type promoter, respectively. The experime …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Drosophila
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
cell line
DNA
DNA-Binding Proteins / metabolism*
Nuclear Proteins / metabolism*
Receptors
Base Sequence
Molecular Sequence Data
Gene Expression Regulation*
Promoter Regions
transcription factors*
sterol regulatory element binding protein 1
ldl / genetics*
ccaat-enhancer-binding proteins*
sp1 transcription factor / metabolism*
h b sanchez
t f osborne
sterols / metabolism*
pmid:7836375
doi:10.1074/jbc.270.3.1161
l yieh
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273096
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