Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses

Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses

James F. Striebel, Brent Race, Jacqueline M. Leung, Cindi Schwartz, Bruce Chesebro;James F. Striebel;Brent Race;Jacqueline M. Leung;Cindi Schwartz;Bruce Chesebro;
acta neuropathologica communications 2021 Vol. 9 pp. -
169
chesebro2021actaprion-induced

Abstract

Accumulation of misfolded host proteins is central to neuropathogenesis of numerous human brain diseases including prion and prion-like diseases. Neurons of retina are also affected by these diseases. Previously, our group and others found that prion-induced ...

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