Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults - Nature
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Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults - Nature

Mulligan, Mark J.;Lyke, Kirsten E.;Kitchin, Nicholas;Absalon, Judith;Gurtman, Alejandra;Lockhart, Stephen;Neuzil, Kathleen;Raabe, Vanessa;Bailey, Ruth;Swanson, Kena A.;Li, Ping;Koury, Kenneth;Kalina, Warren;Cooper, David;Fontes-Garfias, Camila;Shi, Pei-Yong;Türeci, Özlem;Tompkins, Kristin R.;Walsh, Edward E.;Frenck, Robert;Falsey, Ann R.;Dormitzer, Philip R.;Gruber, William C.;Şahin, Uğur;Jansen, Kathrin U.;Mulligan, Mark J.;Lyke, Kirsten E.;Kitchin, Nicholas;Absalon, Judith;Gurtman, Alejandra;Lockhart, Stephen;Neuzil, Kathleen;Raabe, Vanessa;Bailey, Ruth;Swanson, Kena A.;Li, Ping;Koury, Kenneth;Kalina, Warren;Cooper, David;Fontes-Garfias, Camila;Shi, Pei-Yong;Türeci, Özlem;Tompkins, Kristin R.;Walsh, Edward E.;Frenck, Robert;Falsey, Ann R.;Dormitzer, Philip R.;Gruber, William C.;Şahin, Uğur;Jansen, Kathrin U.;
Nature 2020 Vol. 586 pp. 589-593
132
j.2020naturephase i/ii

Abstract

In a dose-escalation study of the COVID-19 RNA vaccine BNT162b1 in 45 healthy adults, RBD-binding IgG concentrations and SARS-CoV-2 neutralizing titres in sera increased with dose level and after a second vaccine dose.

Keywords

viral infection randomized controlled trials drug development sars-cov-2

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DOI:
doi:10.1038/s41586-020-2639-4
URL:
https://www.nature.com/articles/s41586-020-2639-4

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