Baricitinib for the treatment of rheumatoid arthritis and systemic lupus erythematosus: a 2019 update
Abstract
Introduction: JAK, which constitutively binds to some cytokine receptors, plays an important role in cytokine signaling. While JAK is comprised of JAK1, JAK2, JAK3, and Tyk2, more than 40 types of cytokines transmit signals through JAK. Baricitinib is reported to be highly effective in the tr …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Lupus Erythematosus
Systemic / immunology
arthritis
rheumatoid / drug therapy*
signal transduction / drug effects*
yoshiya tanaka
rheumatoid / immunology
clinical trials
phase iii as topic
cytokines / immunology
azetidines / therapeutic use*
sulfonamides / therapeutic use*
systemic / drug therapy*
pmid:30987474
doi:10.1080/1744666x.2019.1608821
satoshi kubo
shingo nakayamada
rheumatoid / pathology
janus kinases / immunology
systemic / pathology
signal transduction / immunology
tyk2 kinase / immunology
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272813
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