Association between the perturbation of bile acid homeostasis and valproic acid-induced hepatotoxicity
Abstract
Valproic acid (VPA), a widely prescribed antiepileptic drug, is known to induce hepatotoxicity. However, the mechanisms underlying this toxicity are not well understood. In this study, we performed a nontargeted metabolomic analysis of children with epilepsy treated with VPA (n = 23). Metabolic path …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
adolescent
Child
Infant
preschool
Liver / metabolism*
lipid metabolism / drug effects
homeostasis / physiology
homeostasis / drug effects*
pmid:31628911
doi:10.1016/j.bcp.2019.113669
yanan chen
jingkai zhou
limei zhao
anticonvulsants / toxicity*
bile acids and salts / metabolism*
lipid metabolism / physiology
liver / drug effects*
metabolomics / methods
valproic acid / toxicity*
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272717
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