Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes
Abstract
Transition metal-catalyzed transfers of carbenes, nitrenes, and oxenes are powerful methods for functionalizing C=C and C-H bonds. Nature has evolved a diverse toolbox for oxene transfers, as exemplified by the myriad monooxygenation reactions catalyzed by cytochrome P450 enzymes. The isoelectronic …
Keywords
catalysis
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
N.I.H.
Extramural
chemical
stereoisomerism
methane / analogs & derivatives*
methane / chemistry
protein engineering
pmid:23258409
doi:10.1126/science.1231434
pedro s coelho
eric m brustad
frances h arnold
alkenes / chemistry*
bacillus megaterium / enzymology
cyclopropanes / chemistry*
cytochrome p-450 enzyme system / chemistry*
cytochrome p-450 enzyme system / genetics
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272653
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