The nature and character of the transition state for the ADP-ribosyltransferase reaction
Abstract
Exotoxin A (ExoA) from Pseudomonas aeruginosa is an important virulence factor that belongs to a class of exotoxins that are secreted by pathogenic bacteria which cause human diseases such as cholera, diphtheria, pneumonia and whooping cough. We present the first crystal structures, to our knowledge …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Molecular
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
mutation
protein binding
bacterial toxins / metabolism
protein structure
structure-activity relationship
mutagenesis
secondary
bacterial toxins / genetics
exotoxins / genetics
x-ray
site-directed
pseudomonas aeruginosa / metabolism*
virulence factors / genetics
crystallography
adp ribose transferases / chemistry
bacterial toxins / chemistry
exotoxins / chemistry
exotoxins / metabolism
virulence factors / chemistry
virulence factors / metabolism
pmid:18583986
pmc2515215
doi:10.1038/embor.2008.90
rené jørgensen
yolanda wang
a rod merrill
adp ribose transferases / genetics
adp ribose transferases / metabolism*
nad / chemistry
nad / metabolism*
peptide elongation factor 2 / chemistry
peptide elongation factor 2 / genetics
peptide elongation factor 2 / metabolism*
pseudomonas aeruginosa / growth & development
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272592
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