Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival
Abstract
An accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR) mediated via the activation of three transmembrane proteins IRE1, PERK and ATF6. Signalling through these proteins is aimed at enhancing the ER folding capacity and reducing the foldi …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
cell line
DNA-Binding Proteins / metabolism*
Transcription Factors / metabolism*
signal transduction
protein-serine-threonine kinases / metabolism*
endoribonucleases / metabolism*
apoptosis / physiology
membrane proteins / metabolism*
regulatory factor x transcription factors
x-box binding protein 1
cell survival / physiology
pmid:25633195
pmc4532775
doi:10.1038/cdd.2014.241
f walter
j schmid
j h m prehn
activating transcription factor 4 / metabolism*
endoplasmic reticulum stress / physiology*
single-cell analysis / methods
unfolded protein response
eif-2 kinase / metabolism*
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272573
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