In vitro and in vivo activities of anti-influenza virus compound T-705
Abstract
T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) has been found to have potent and selective inhibitory activity against influenza virus. In an in vitro plaque reduction assay, T-705 showed potent inhibitory activity against influenza A, B, and C viruses, with 50% inhibitory concentrations (IC(50)s) …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
male
cell line
Inbred BALB C
microbial sensitivity tests
antiviral agents / therapeutic use*
antiviral agents / pharmacology*
influenza
human / drug therapy*
lung / virology
human / virology
drug screening assays
antitumor
k takahashi
orthomyxoviridae / drug effects*
amides / therapeutic use*
pyrazines / therapeutic use*
pmid:11897578
pmc127093
doi:10.1128/aac.46.4.977-981.2002
y furuta
k shiraki
amides / pharmacology*
pyrazines / pharmacology*
viruses / drug effects
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272486
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