Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene
Abstract
Neuropeptide Y (NPY), a peptide synthesized in the hypothalamic arcuate nucleus, is implicated in the physiologic control of food intake and body weight. Because both genetic (e.g. in obese ob/ob mice) and acquired leptin deficiency (e.g. fasting in normal mice) increase hypothalamic NPY accumulatio …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
gene expression
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
P.H.S.
mutation
Knockout
transcription
kinetics
proteins / genetics
hypothalamus / metabolism*
leptin
proteins / physiology*
obese
fasting*
arcuate nucleus of hypothalamus / metabolism
pmid:9564880
doi:10.1210/endo.139.5.6000
m w schwartz
j c erickson
r d palmiter
neuropeptide y / genetics*
proteins / pharmacology
beta-galactosidase / genetics*
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272480
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