Chloroquine antagonizes the proinflammatory cytokine response to opportunistic fungi by alkalizing the fungal phagolysosome
Abstract
Recent observations demonstrated that the antimalarial drug chloroquine (CQ) can kill the opportunistic fungus Cryptococcus neoformans. Since CQ blunts lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha release, it was hypothesized that this drug would also interfere with the inflamm …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
Cells
Cultured
genetic / drug effects
transcription
enzyme inhibitors / pharmacology
anti-bacterial agents / pharmacology
leukocytes
mononuclear / immunology
cell survival / drug effects
cytokines / biosynthesis
cell nucleus / metabolism
nf-kappa b / metabolism
hiv seropositivity / immunology*
cell nucleus
tumor necrosis factor-alpha / biosynthesis*
tumor necrosis factor-alpha / genetics
chloroquine / pharmacology*
s m levitz
pmid:11237811
doi:10.1086/319259
s m weber
active transport
ammonium chloride / pharmacology
candida albicans / immunology*
cryptococcus neoformans / immunology*
endosomes / drug effects
hydrogen-ion concentration / drug effects
lysosomes / drug effects*
macrolides*
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272478
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