Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain
Abstract
Cre-mediated gene manipulation using transgenic lines that express Cre under the control of the Ins2 and Pdx1 promoters are likely to alter gene expression in nutrient-sensing neurons. Therefore, data arising from the use of these transgenic Cre lines must be interpreted carefully to assess whether …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
female
male
N.I.H.
Extramural
Genes
Crosses
immunohistochemistry
transgenic
swine
reverse transcriptase polymerase chain reaction
immunoglobulin g
insulin-secreting cells / physiology*
integrases / genetics*
gene targeting / methods*
brain / physiology
pmid:20802254
pmc2992770
doi:10.2337/db10-0624
barton wicksteed
marcela brissova
peter j dempsey
estrogen antagonists / pharmacology
galactosides / metabolism
reporter / genetics
insulin / immunology
leptin / pharmacology
tamoxifen / pharmacology*
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272472
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