Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
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Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

Hanzlikova, Hana;Prokhorova, Evgeniia;Krejcikova, Katerina;Cihlarova, Zuzana;Kalasova, Ilona;Kubovciak, Jan;Sachova, Jana;Hailstone, Richard;Brazina, Jan;Ghosh, Shereen;Cirak, Sebahattin;Gleeson, Joseph G.;Ahel, Ivan;Caldecott, Keith W.;
Nature communications 2020 Vol. 11 pp. 1-13
56
hanzlikova2020pathogenicnature

Abstract

Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand breaks.

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Zoology Microbiology Botany Engineering (General). Civil engineering (General) Science general. including nature conservation, geographical distribution geology

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https://doi.org/10.1038/s41467-020-17069-9

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