Prostate tumor progression is mediated by a paracrine TGF-β/Wnt3a signaling axis - Oncogene
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Prostate tumor progression is mediated by a paracrine TGF-β/Wnt3a signaling axis - Oncogene

Li, X;Placencio, V;Iturregui, J M;Uwamariya, C;Sharif-Afshar, A-R;Koyama, T;Hayward, S W;Bhowmick, N A;Li, X;Placencio, V;Iturregui, J M;Uwamariya, C;Sharif-Afshar, A-R;Koyama, T;Hayward, S W;Bhowmick, N A;
Oncogene 2008 Vol. 27 pp. 7118-7130
261
x2008oncogeneprostate1

Abstract

Transforming growth factor (TGF)-β is an important paracrine factor in tumorigenesis. Ligand binding of the type I and II TGF-β receptors initiate downstream signaling. The role of stromal TGF-β signaling in prostate cancer progression is unknown. In mice, the conditional stromal knockout of the TGF-β type II receptor expression (Tgfbr2fspKO) resulted in the development of prostatic intraepithelial neoplasia and progression to adenocarcinoma within 7 months. Clinically, we observed a loss of TGF-β receptor type II expression in 69% of human prostate cancer-associated stroma, compared to 15% of stroma associated with benign tissues (n=140, P-value

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cell biology oncology apoptosis internal medicine general medicine/public health human genetics

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DOI:
doi:10.1038/onc.2008.293
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https://doi.org/10.1038%2Fonc.2008.293

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