Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation
Abstract
Notch pathway is crucial for stem/progenitor cell maintenance, growth and differentiation in a variety of tissues. Using a transgenic cell ablation approach, we found in our previous study that cells expressing Notch1 are crucial for prostate early development and re-growth. Here, we further define …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
male
newborn
Cells
Cultured
Knockout
cell proliferation*
oligonucleotide array sequence analysis
stem cells / cytology
stem cells / metabolism*
cell transformation
neoplastic
down-regulation
receptor
epithelial cells / cytology
Prostate / metabolism*
cell cycle proteins / metabolism
epithelial cells / metabolism*
cell differentiation*
morphogenesis
prostate / growth & development
pmid:16360140
doi:10.1016/j.ydbio.2005.11.009
xi-de wang
ching ching leow
wei-qiang gao
amyloid precursor protein secretases
aspartic acid endopeptidases
basic helix-loop-helix transcription factors / metabolism
endopeptidases / metabolism
keratins / metabolism
protease inhibitors / pharmacology
notch1 / genetics
notch1 / metabolism*
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271697
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