Aurora-A - a guardian of poles
Abstract
The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centro …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
neoplasms / pathology
cell transformation
neoplastic
aurora kinases
xenopus proteins
cell cycle proteins
protein-serine-threonine kinases
mitosis / physiology*
pmid:15630414
doi:10.1038/nrc1526
tomotoshi marumoto
dongwei zhang
hideyuki saya
kinetochores
neoplasms / enzymology*
protein kinases / physiology*
spindle apparatus*
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271670
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