Minor class splicing shapes the zebrafish transcriptome during development
Abstract
Minor class or U12-type splicing is a highly conserved process required to remove a minute fraction of introns from human pre-mRNAs. Defects in this splicing pathway have recently been linked to human disease, including a severe developmental disorder encompassing brain and skeletal abnormalities kn …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
gene expression regulation
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
N.I.H.
Extramural
Sequence Analysis
Base Sequence
Molecular Sequence Data
gene expression profiling
zebrafish / genetics*
zebrafish proteins / genetics*
developmental / physiology*
real-time polymerase chain reaction
developmental / genetics
microarray analysis
protein conformation*
pmid:24516132
pmc3939875
doi:10.1073/pnas.1305536111
sebastian markmiller
nicole cloonan
joan k heath
intestines / abnormalities
liver / abnormalities
pancreas / abnormalities
point mutation / genetics
rna splicing / genetics
rna splicing / physiology*
small nuclear / chemistry*
rna-binding proteins / genetics*
rna-binding proteins / metabolism
spliceosomes / genetics
spliceosomes / metabolism*
zebrafish / growth & development
zebrafish proteins / metabolism
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