Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine
Abstract
Methotrexate (MTX) is an anti-metabolite, widely used in the cancer chemotherapy and rheumatoid arthritis. However, its long-term clinical use is restricted on account of its severe intestinal toxicity. The present study was aimed to investigate the intestinal toxicity of MTX and the possible protec …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
Rats
Sprague-Dawley
malondialdehyde / metabolism
oxidative stress / drug effects
dna damage
in situ nick-end labeling
antimetabolites
methotrexate / toxicity*
tumor suppressor protein p53 / metabolism
intestines / drug effects*
intestines / pathology
comet assay
pmid:19900424
doi:10.1016/j.cbi.2009.10.020
v p dadhania
d n tripathi
g b jena
alkaline phosphatase / metabolism
antineoplastic / toxicity*
glutathione / metabolism
thioctic acid / pharmacology*
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