Interleukin-12 regulates the response to chemotherapy in experimental visceral Leishmaniasis
Abstract
In experimental visceral leishmaniasis, interleukin (IL)-12 initiates control over Leishmania donovani via Th1 cell activation, interferon (IFN)-gamma secretion, and granuloma formation. Because the leishmanicidal effect of conventional therapy, pentavalent antimony (Sb), also requires T cells and e …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
P.H.S.
Inbred BALB C
Knockout
leishmaniasis
h w murray
antimony / therapeutic use
visceral / drug therapy*
pmid:11023473
doi:10.1086/315890
c montelibano
j p sypek
interferon-gamma / physiology
interleukin-12 / physiology*
interleukin-4 / physiology
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271536
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