Cdkn2a encodes functional variation of p16INK4a but not p19ARF, which confers selection in mouse lung tumorigenesis
Abstract
The cyclin-dependent kinase inhibitor 2a (Cdkn2a) locus encodes two distinct tumor suppressors, p16INK4a and p19ARF, whose functions interrelate in the regulation of cell proliferation as key components of the retinoblastoma and p53 pathways, respectively. In many types of cancer, alterations of Cdk …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
P.H.S.
Polymorphism
mutation
proteins / genetics*
reverse transcriptase polymerase chain reaction
cell transformation
Tumor Suppressor Protein p14ARF
jurkat cells
neoplastic / genetics
adenocarcinoma / genetics*
pmid:10365910
doi:10.1002/(sici)1098-2744(199906)25:23.0.co;2-2
c r herzog
s noh
m you
cyclin-dependent kinase inhibitor p16 / genetics*
lung neoplasms / genetics*
single-stranded conformational
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271444
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