A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells
Abstract
IL-10 is a cytokine secreted by a wide variety of cells type that has pleiotropic stimulatory and suppressive activities on both lymphoid and myeloid cells in vitro. To analyze the consequences of high IL-10 secretion by APCs in immune responses, we produced transgenic mice expressing human IL-10 di …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
polymerase chain reaction
Inbred BALB C
Base Sequence
transgenic
recombinant proteins
lymphocyte activation
t-lymphocytes / immunology
up-regulation
inbred dba
dna primers / genetics
interleukin-10 / metabolism
monocytes / immunology
b-lymphocytes / immunology
pmid:9973435
h groux
f cottrez
r l coffman
antigen-presenting cells / immunology*
interferon-gamma / pharmacology
interleukin-10 / genetics
interleukin-10 / immunology*
leishmania major / immunology
leishmania major / pathogenicity
listeria monocytogenes / immunology
listeria monocytogenes / pathogenicity
mast-cell sarcoma / immunology
ovalbumin / immunology
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271438
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